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KMID : 0616120090400040345
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Korean Journal of Pharmacognosy
2009 Volume.40 No. 4 p.345 ~ p.350
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Antioxidative and Hepatoprotective Effect of Compounds from the Flowers of Bidens bipinnata L.
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Gwon Ji-Woong
Byun Erisa
Lee Eoh-Jin
Kim Youn-Chul
Jeong Gil-Saeng
An Ren-Bo
Gwon Tae-Oh
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Abstract
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Activity-guided fractionation of the EtOH extract of flowers of Bidens bipinnata L. have been furnished five flavonoids,
sulfuretin(1), butein(2), 7,8,3’,4’-tetrahydroxyflavanone(3), maritimetin(4) and okanin(5). All of the compounds
showed significant activities on both linoleic acid peroxidation inhibition and DPPH radical scavenging effect. The evaluation for protective effect of isolated compounds against tacrine-induced cytotoxicity in human liver-derived Hep G2 cells was conducted. Compounds 1, 3, 4 and 5 showed significant protective effects with the EC50 values of 36.1±0.9, 23.3±0.7, 41.0±1.0 and 29.8±1.1 μM, respectively. Silybin, one of the well-known hepatoprotective agents, used as a positive control, and also showed protective effect with an EC50 value of 84.3±0.7 μM.
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KEYWORD
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Bidens bipinnata L., antioxidative, hepatoprotective, Hep G2 cells, tacrine
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